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Fetal Malformations Linked to Anti-epilepsy Drugs

A study in the February 25, 2003 issue of Neurology reports that the children of women who took anti-epileptic drugs during pregnancy have a higher incidence of malformations.

The study followed 970 pregnant women with epilepsy. 740 out of 979 children born to the women were exposed to anti-epileptic drugs during the first trimester (the time when fetal formation and development occurs).

Major malformations were detected in 28 children (3.8%) who were exposed to the drugs. Only 2 children (0.8%) who were not exposed to the drugs had problems.

In an obvious understatement, the authors say, “New [anti-epileptic drugs]…should be thoroughly investigated with regard to their [malformation causing] potential.”

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